Glucose-6-phosphate dehydrogenase and Neurospora morphology.
نویسندگان
چکیده
In addition to the Neurospora crassa mutant col-2, mutations in two other unlinked genes, balloon and frost, lead to distinct morphological growth and abnormal glucose-6-phosphate dehydrogenases. The glucose-6-phosphate dehydrogenases from these strains have increased thermolabilities, altered kinetic parameters, and distinctive electrofocusing patterns. The altered enzyme segregates with each morphological phenotype in crosses to wild type, and there is a correlation between the severity of the enzymic defect and the degree of morphological abnormality in heterocaryons and double mutants. These results are compatible with the hypotheses that the balloon, frost, and col-2 genes are structural genes for glucose-6-phosphate dehydrogenase and that the pleiotropic effects of these altered dehydrogenases are responsible for the mutant morphologies.
منابع مشابه
Physical properties of glucose 6-phosphate dehydrogenase from Neurospora crassa.
Neurospora glucose 6-phosphate dehydrogenase is a multimerit protein and occurs as tetramers and dimers with molecular weights of 206,000 and 104,000 to 114,000, respectively. The existence of the two types of molecules is supported by electron microscopic observations. The molecular weight of the subunits was estimated to be 57,000 by sodium dodecyl sulfate gel electrophoresis, and 63,000 by s...
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Neurospora glucose 6-phosphate dehydrogenase is a multimerit protein and occurs as tetramers and dimers with molecular weights of 206,000 and 104,000 to 114,000, respectively. The existence of the two types of molecules is supported by electron microscopic observations. The molecular weight of the subunits was estimated to be 57,000 by sodium dodecyl sulfate gel electrophoresis, and 63,000 by s...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 66 2 شماره
صفحات -
تاریخ انتشار 1970